Safety data summary
Isopropanol
Isopropanol (CAS 67-63-0) is a chemical substance with the molecular formula C3H8O and a molecular weight of 60.1 g/mol. Under the EU harmonised GHS classification (CLP Annex VI), it carries the signal word “Danger” and is classified as flammable and an irritant. Its label shows the Flame and Exclamation Mark pictograms. Key hazard statements include H225 (highly Flammable liquid and vapor), H319 (causes serious eye irritation), and H336 (may cause drowsiness or dizziness). The OSHA permissible exposure limit (PEL) is 400 ppm (980 mg/m³).
Hazards at a glance
- H225Highly Flammable liquid and vapor
- H319Causes serious eye irritation
- H336May cause drowsiness or dizziness
Regulation (EC) No 1272/2008 of the European Parliament and of the Council — harmonised classification (CLP Annex VI)
1Identification
- Name
- Isopropanol
- IUPAC name
- propan-2-ol
- CAS number
- 67-63-0
- EC number
- 200-661-7
- Molecular formula
- C3H8O
- Molecular weight
- 60.1 g/mol
- InChIKey
- KFZMGEQAYNKOFK-UHFFFAOYSA-N
- SMILES
- CC(C)O
- PubChem CID
- 3776
- Synonyms
- Isopropyl alcohol, isopropanol, 2-Propanol, Propan-2-ol, 2-Hydroxypropane, Dimethylcarbinol, sec-Propyl alcohol, Alkolave, Avantine, Hartosol, Petrohol, i-Propanol, 1-Methylethanol, Takineocol
Recommended uses
- CIR ingredient: Isopropyl AlcoholCosmetic Ingredient Review (CIR)
- Used as a fuel antifreeze and an intermediate in the synthesis of organic chemicals; also used as a solvent for oils, resins, cosmetics, and many other household products; [ACGIH] Used as a disinfectant; [www.healthcouncil.nl]Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Semiconductor Manufacturing [Category: Industry] Painting (Solvents) [Category: Paint] Using Disinfectants or Biocides [Category: Clean] Silk-Screen Printing [Category: Other]Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Intermediate Processing aids, specific to petroleum production Flotation agent Drier Adhesion/cohesion promoter Pigment Laboratory chemicals Surface modifier Cleaning agent Flux agent Emulsifier Soil amendments (fertilizers) Catalyst Waterproofing agent Diluent Corrosion inhibitor Not Known or Reasonably Ascertainable Stabilizing agent Sealant (barrier) Refrigerants Surfactant (surface active agent) Semiconductor and photovoltaic agent Processing aids not otherwise specified Solubility enhancer Fuel agents Fuel Heat transferring agent Anti-freeze agent Dispersing agent Solvent Lubricating agent Freeze-thaw additive OtherEPA Chemical Data Reporting (CDR)
- Catalyst Diluent Corrosion inhibitor Not Known or Reasonably Ascertainable Emulsifier Soil amendments (fertilizers) Cleaning agent Laboratory chemicals Processing aids, specific to petroleum production Intermediate Pigment Freeze-thaw additive Lubricating agent Other Insulators Anti-freeze agent Dispersing agent Solvent Fuel agents Fuel Heat transferring agent Semiconductor and photovoltaic agent Surfactant (surface active agent) Processing aids not otherwise specifiedEPA Chemical Data Reporting (CDR)
Use categories: EPA Safer Chemical Functional Use Classes -> Antimicrobial Actives;Solvents · Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern · Fragrance Ingredients · Flavouring Agent -> FLAVOURING_AGENTFood Additives -> CARRIER_SOLVENT; EXTRACTION_SOLVENT -> JECFA Functional Classes
Description
- Volatile, colorless liquid with a sharp musty odor like rubbing alcohol. Flash point of 53 °F. Vapors are heavier than air and mildly irritating to the eyes, nose, and throat. Density approximately 6.5 lb / gal. Used in making cosmetics, skin and hair preparations, pharmaceuticals, perfumes, lacquer formulations, dye solutions, antifreezes, soaps, window cleaners. Sold in 70% aqueous solution as rubbing alcohol.CAMEO Chemicals
- Propan-2-ol is a secondary alcohol that is propane in which one of the hydrogens attached to the central carbon is substituted by a hydroxy group. It has a role as a protic solvent. It is a secondary fatty alcohol and a secondary alcohol.ChEBI
- An isomer of 1-propanol. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.DrugBank
2Hazard identification
- Signal word
- Danger
- Pictograms
- GHS02, GHS07
- Classification source
- Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Precautionary statements
| Code | Statement |
|---|---|
| P210 | Keep away from heat, hot surface, sparks, open flames and other ignition sources. No smoking. |
| P233 | Keep container tightly closed. |
| P240 | Ground/bond container and receiving equipment. |
| P241 | Use explosion-proof [electrical/ventilating/lighting/.../] equipment. |
| P242 | Use only non-sparking tools. |
| P243 | Take precautionary measures against static discharge. |
| P261 | Avoid breathing dust/fume/gas/mist/vapors/spray. |
| P264+P265 | Wash hands [and ...] thoroughly after handling. Do not touch eyes. |
| P271 | Use only outdoors or in a well-ventilated area. |
| P280 | Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... |
| P303+P361+P353 | IF ON SKIN (or hair): Take off Immediately all contaminated clothing. Rinse SKIN with water [or shower]. |
| P304+P340 | IF INHALED: Remove person to fresh air and keep comfortable for breathing. |
| P305+P351+P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. |
| P319 | Get medical help if you feel unwell. |
| P337+P317 | If eye irritation persists: Get medical help. |
| P370+P378 | In case of fire: Use ... to extinguish. |
| P403+P233 | Store in a well-ventilated place. Keep container tightly closed. |
| P403+P235 | Store in a well-ventilated place. Keep cool. |
| P405 | Store locked up. |
| P501 | Dispose of contents/container to ... |
Other reported classifications
6 classification records exist across sources. Differences usually reflect purity, physical form or impurities.
| Source | Signal | Hazard codes |
|---|---|---|
| Regulation (EC) No 1272/2008 of the European Parliament and of the Council | Danger | H318, H373, H400, H410 |
| European Chemicals Agency (ECHA) | Danger | H225, H319, H336 |
| NITE-CMC | Danger | H225, H319, H335, H361, H370, H372, H373 |
| NITE-CMC | Danger | H225, H303, H305, H313, H319, H335, H361, H370, H373 |
NFPA 704 rating
- 1 - Materials that, under emergency conditions, can cause significant irritation.Hazardous Substances Data Bank (HSDB)
- 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.Hazardous Substances Data Bank (HSDB)
- 0 - Materials that in themselves are normally stable, even under fire conditions.Hazardous Substances Data Bank (HSDB)
Health hazards
- Vapors cause mild irritation of eyes and upper respiratory tract; high concentrations may be anesthetic. Liquid irritates eyes and may cause injury; harmless to skin; if ingested causes drunkenness and vomiting. (USCG, 1999)CAMEO Chemicals
- · May cause toxic effects if inhaled or absorbed through skin. · Inhalation or contact with material may irritate or burn skin and eyes. · Fire will produce irritating, corrosive and/or toxic gases. · Vapors may cause dizziness or asphyxiation, especially when in closed or confined areas. · Runoff from fire control or dilution water may cause environmental contamination.Emergency Response Guidebook (ERG)
- · Inhalation of material may be harmful. · Contact may cause burns to skin and eyes. · Inhalation of Asbestos dust may have a damaging effect on the lungs. · Fire may produce irritating, corrosive and/or toxic gases. · Some liquids produce vapors that may cause dizziness or asphyxiation. · Runoff from fire control or dilution water may cause environmental contamination.Emergency Response Guidebook (ERG)
Fire hazards
- Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids will float on water. (ERG, 2024)CAMEO Chemicals
- · HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. · Vapors may form explosive mixtures with air. · Vapors may travel to source of ignition and flash back. · Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.). · Vapor explosion hazard indoors, outdoors or in sewers. · Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. · Runoff to sewer may create fire or explosion hazard. · Containers may explode when heated. · Many liquids will float on water.Emergency Response Guidebook (ERG)
- · Some may burn but none ignite readily. · Containers may explode when heated. · Some may be transported hot. · For UN3508, Capacitor, asymmetric, be aware of possible short circuiting as this product is transported in a charged state. · Polymeric beads, expandable (UN2211) may evolve flammable vapours.Emergency Response Guidebook (ERG)
Hazards summary
- Isopropyl alcohol causes narcosis in acute animal studies. [ACGIH] Isopropyl alcohol is not hepatotoxic in experimental animal studies or in human exposures. [Zimmerman, p. 367] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC]Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
3Composition / information on ingredients
| Substance | CAS | EC | Formula |
|---|---|---|---|
| Isopropanol | 67-63-0 | 200-661-7 | C3H8O |
This page describes the pure substance. Commercial products may be solutions or mixtures. Check Section 3 of your supplier's SDS for concentrations and other ingredients.
4First-aid measures
- EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water.CAMEO Chemicals
- General First Aid: · Call 911 or emergency medical service. · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination. · Move victim to fresh air if it can be done safely. · Administer oxygen if breathing is difficult. · If victim is not breathing: -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance. -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).Emergency Response Guidebook (ERG)
- (General first aid procedures) Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Skin: Water flush - If this chemical contacts the skin, flush the contaminated skin with water. Where there is evidence of skin irritation, get medical attention. Breathing: Respiratory support Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.The National Institute for Occupational Safety and Health (NIOSH)
Symptoms of exposure
- Sore throat. Cough. Headache. Dizziness. Drowsiness. Further see Ingestion.ILO-WHO International Chemical Safety Cards (ICSCs)
- Dry skin.ILO-WHO International Chemical Safety Cards (ICSCs)
- Redness. Pain. Blurred vision. Burns.ILO-WHO International Chemical Safety Cards (ICSCs)
5Fire-fighting measures
- If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.Hazardous Substances Data Bank (HSDB)
- Do not use a solid (straight) water stream as it may scatter and spread fire. /Isopropyl Alcohol, Reagent, ACS/Hazardous Substances Data Bank (HSDB)
Hazardous combustion products
- Hazardous Combustion Products: Carbon monoxide; carbon dioxide. /Isopropyl Alcohol, Reagent, ACS/Hazardous Substances Data Bank (HSDB)
6Accidental release measures
Isolation and evacuation
- Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)CAMEO Chemicals
- Immediate precautionary measure · Isolate spill or leak area for at least 50 meters (150 feet) in all directions. Large Spill · Consider initial downwind evacuation for at least 300 meters (1000 feet). Fire · If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.Emergency Response Guidebook (ERG)
Spill cleanup
- Evacuate danger area! Consult an expert! Remove all ignition sources. Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable non-plastic containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Wash away remainder with plenty of water.ILO-WHO International Chemical Safety Cards (ICSCs)
- Accidental Release Measures: Personal Precautions: Ensure adequate ventilation. Keep people away from and upwind of spill/leak. Avoid contact with skin, eyes and clothing. Use personal protective equipment. Remove all sources of ignition. Pay attention to flashback. Take precautionary measures against static discharges. All equipment used when handling the product must be grounded. Use spark-proof tools and explosion-proof equipment. In case of large spill, water spray or vapor suppressing foam may be used to reduce vapors, but may not prevent ignition in closed spaces. /Isopropyl Alcohol, Reagent, ACS/Hazardous Substances Data Bank (HSDB)
- Accidental Release Measures: Environmental Precautions: Prevent further leakage or spillage if safe to do so. Prevent entry into waterways, sewers, basements or confined areas. In case of large spill, dike if needed. Dike far ahead of liquid spill for later disposal. /Isopropyl Alcohol, Reagent, ACS/Hazardous Substances Data Bank (HSDB)
- Accidental Release Measures: Methods for Cleaning Up: Absorb spill with inert material (e.g. vermiculite, dry sand or earth), then place in a suitable chemical waste container. Clean contaminated surface thoroughly. /Isopropyl Alcohol, Reagent, ACS/Hazardous Substances Data Bank (HSDB)
7Handling and storage
- Fireproof. Separated from strong oxidants. Cool. Well closed.ILO-WHO International Chemical Safety Cards (ICSCs)
- Keep container tightly closed in a dry and well-ventilated place. Store at room temperature in the original container. Sensitive to light. Store in light-resistant containers. Keep away from heat and sources of ignition. Store in a segrated and approved area. Store away from incompatible materials. /Isopropyl Alcohol, Reagent, ACS/Hazardous Substances Data Bank (HSDB)
- Store in tightly closed containers in a cool, well ventilated area away from heat.Hazardous Substances Data Bank (HSDB)
8Exposure controls / personal protection
| Limit | Value | Source |
|---|---|---|
| OSHA PEL | 400.0 [ppm] | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| OSHA PEL | 400 ppm (980 mg/m³) | Occupational Safety and Health Administration (OSHA) |
| NIOSH REL | 400 ppm (980 mg/m³) | Occupational Safety and Health Administration (OSHA) |
| NIOSH REL | 500 ppm (1225 mg/m³) | Occupational Safety and Health Administration (OSHA) |
| ACGIH TLV | 200.0 [ppm] | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| ACGIH TLV | 400.0 [ppm] | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| IDLH | 2000 ppm ; Based on 10% of the lower explosive limit. (NIOSH, 2024) | CAMEO Chemicals |
| IDLH | 2000.0 [ppm] Excerpts from Documentation for IDLHs: Ten volunteers exposed for 3 to 5 minutes to 200, 400, or 800 ppm reported mild to moderate irritation of the eyes, nose, and throat at the two higher concentrations [Nelson et al. 1943]. | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
Personal protective equipment
- Excerpt from NIOSH Pocket Guide for Isopropyl alcohol: Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact. Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact. Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated. Remove: WHEN WET (FLAMMABLE) - Work clothing that becomes wet should be immediately removed due to its flammability hazard (i.e., for liquids with a flash point <100 °F). Change: No recommendation is made specifying the need for the worker to change clothing after the workshift. (NIOSH, 2024)CAMEO Chemicals
- Personal Protective Equipment: Eye protection: goggles, safety glasses with side-shields. Skin and body protection: chemical resistant apron, long sleeved clothing, gloves. Respiratory protection: vapor respirator, . be sure to use an approved/certified respirator or equivalent. /Isopropyl Alcohol, Reagent, ACS/Hazardous Substances Data Bank (HSDB)
- The following materials are acceptable: neoprene, PVC, paracril/PVC, chlorinated polyethylene, butyl rubber, natural rubber, nitrile, vitron. Unacceptable: PVA. Conditionally acceptable: polyurethane. Note: This ... is ... a guide only. The user is advised to contact the protective clothing manufacturer regarding the specific applicability & limitations of a material under proposed conditions of use.Hazardous Substances Data Bank (HSDB)
- Personnel protection: Wear appropriate chemical protective gloves, boots and goggles.Hazardous Substances Data Bank (HSDB)
Respirator recommendations
- NIOSH/OSHA Up to 2000 ppm: (APF = 25) Any supplied-air respirator operated in a continuous-flow mode (APF = 50) Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s) (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister (APF = 25) Any powered, air-purifying respirator with organic vapor cartridge(s) (APF = 50) Any self-contained breathing apparatus with a full facepiece (APF = 50) Any supplied-air respirator with a full facepiece Emergency or planned entry into unknown concentrations or IDLH conditions: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece…The National Institute for Occupational Safety and Health (NIOSH)
9Physical and chemical properties
| Molecular weight | 60.1 g/mol |
|---|---|
| Physical description | Volatile, colorless liquid with a sharp musty odor like rubbing alcohol. Flash point of 53 °F. Vapors are heavier than air and mildly irritating to the eyes, nose, and throat. Density approximately 6.5 lb / gal. Used in making cosmetics, skin and hair preparations, pharmaceuticals, perfumes, lacquer formulations, dye solutions, antifreezes, soaps, window cleaners. Sold in 70% aqueous solution as rubbing alcohol. CAMEO Chemicals Liquid; Liquid; Other Solid; Gas Vapor; Dry Powder; Other Solid; Wet Solid; Large Crystals; CBI EPA Chemical Data Reporting (CDR) |
| Color / form | Colorless liquid Hazardous Substances Data Bank (HSDB) |
| Odor | Pleasant odor Hazardous Substances Data Bank (HSDB) Slight odor resembling that of a mixture of ethanol and acetone Hazardous Substances Data Bank (HSDB) |
| Boiling point | 180.5 °F at 760 mmHg (NTP, 1992) CAMEO Chemicals 82.3 °C DrugBank 82.3 °C at 760 mm Hg Hazardous Substances Data Bank (HSDB) |
| Melting point | -127.3 °F (NTP, 1992) CAMEO Chemicals -89.5 °C DrugBank -87.9 °C Hazardous Substances Data Bank (HSDB) |
| Flash point | 53 °F (NTP, 1992) CAMEO Chemicals 12 °C Haz-Map, Information on Hazardous Chemicals and Occupational Diseases 12 °C, 53 °F (Closed cup) Hazardous Substances Data Bank (HSDB) |
| Autoignition temperature | 750 °F (USCG, 1999) CAMEO Chemicals 399 °C (750 °F) Hazardous Substances Data Bank (HSDB) |
| Density / specific gravity | 0.785 at 68 °F (USCG, 1999) - Less dense than water; will float CAMEO Chemicals 0.78509 at 25 °C Hazardous Substances Data Bank (HSDB) |
| Vapor density | 2.07 (NTP, 1992) - Heavier than air; will sink (Relative to Air) CAMEO Chemicals 2.1 (Air = 1) Hazardous Substances Data Bank (HSDB) |
| Vapor pressure | 33 mmHg at 68 °F ; 40 mmHg at 74.8 °F (NTP, 1992) CAMEO Chemicals 45.4 [mmHg] Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| Solubility | greater than or equal to 100 mg/mL at 72 °F (NTP, 1992) CAMEO Chemicals 1000000 mg/L (at 25 °C) DrugBank Miscible with alcohol, ether, chloroform; insoluble in salt solution Hazardous Substances Data Bank (HSDB) |
| log Kow (LogP) | 0.05 DrugBank log Kow = 0.05 Hazardous Substances Data Bank (HSDB) |
| Viscosity | 2.038 mPa s at 25 °C Hazardous Substances Data Bank (HSDB) |
| Odor threshold | Odor Threshold Low: 1.0 [ppm] Odor Threshold High: 610.0 [ppm] Detection odor threshold from AIHA (mean = 43 ppm) Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| Decomposition | When heated to decomposition it emits acrid smoke and fumes. Hazardous Substances Data Bank (HSDB) |
| Explosive / flammable limits | 2 % (NTP, 1992) CAMEO Chemicals 2.0% Occupational Safety and Health Administration (OSHA) 12 % (NTP, 1992) CAMEO Chemicals 12.7% at 200 °F Occupational Safety and Health Administration (OSHA) Lower flammable limit: 2.0% by volume; Upper flammable limit: 12.7% by volume @ 200 °F (93 °C) Hazardous Substances Data Bank (HSDB) |
10Stability and reactivity
Reactivity
- ISOPROPANOL reacts with air or oxygen to form dangerously unstable peroxides. Contact with 2-butanone increases the rate of peroxide formation. An explosive reaction occurs when it is heated with (aluminum isopropoxide + crotonaldehyde). Forms explosive mixtures with trinitromethane and hydrogen peroxide. Reacts with barium perchlorate to form a highly explosive compound. Ignites on contact with dioxygenyl tetrafluoroborate, chromium trioxide and potassium-tert-butoxide. Vigorous reactions occur with (hydrogen + palladium), nitroform, oleum, COCl2, aluminum triisopropoxide and oxidizing agents. Reacts explosively with phosgene in the presence of iron salts.CAMEO Chemicals
- Highly flammable. Water soluble.CAMEO Chemicals
Incompatible materials and hazardous reactions
- During distillation of 2-propanol recovered from the reduction of crotonaldehyde with aluminium isopropoxide, a violent explosion occurred. This was attributed either to peroxidized diisopropyl ether (a possible by-product) or to peroxidized crotonaldehyde.Hazardous Substances Data Bank (HSDB)
- Forms explosive mixtures with trinitromethane; hydrogen peroxide (similar in power and sensitivity to glyceryl nitrate). Reacts with barium perchlorate to form the highly explosive propyl perchlorate.Hazardous Substances Data Bank (HSDB)
- When a stream of hydrogen entrained isopropyl alcohol vapors and palladium particles, the mixture caught fire on exposure to air.Hazardous Substances Data Bank (HSDB)
Chemical stability
- Preserve in tight containers, remove from heat.Hazardous Substances Data Bank (HSDB)
11Toxicological information
Routes of exposure
- The substance can be absorbed into the body by inhalation of its vapour.ILO-WHO International Chemical Safety Cards (ICSCs)
- inhalation, ingestion, skin and/or eye contactThe National Institute for Occupational Safety and Health (NIOSH)
Target organs
- Eyes, skin, respiratory systemThe National Institute for Occupational Safety and Health (NIOSH)
Short-term exposure effects
- The substance is irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause unconsciousness.ILO-WHO International Chemical Safety Cards (ICSCs)
Long-term exposure effects
- Repeated or prolonged contact with skin may cause dryness and cracking.ILO-WHO International Chemical Safety Cards (ICSCs)
Carcinogen classification
- Isopropyl alcoholInternational Agency for Research on Cancer (IARC)
- Group 3: Not classifiable as to its carcinogenicity to humansInternational Agency for Research on Cancer (IARC)
- Volume 15: (1977) Some Fumigants, the Herbicides 2,4-D and 2,4,5-T, Chlorinated Dibenzodioxins and Miscellaneous Industrial Chemicals Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide (Part 1, Part 2, Part 3)International Agency for Research on Cancer (IARC)
- 1999International Agency for Research on Cancer (IARC)
12Ecological information
Environmental fate
- Isopropanol's production and use in the manufacture of acetone, glycerol, and isopropyl acetate and as a solvent for a variety of applications may result in its release to the environment through various waste streams. Isopropanol's use in hydraulic fracturing fluids results in its direct release to the environment. Isopropanol has been identified as a metabolic product of aerobic microorganisms, anaerobic microorganisms, fungi, and yeast. If released to air, a vapor pressure of 45.4 mm Hg at 25 °C indicates isopropanol will exist solely as a vapor in the ambient atmosphere.Hazardous Substances Data Bank (HSDB)
Ecotoxicity
- EC50; Species: Daphnia magna (Water Flea) age <24 hr neonate; Conditions: freshwater, static, 21 °C, pH 7.6; Concentration: 114 mM for 24 hr; Effect: intoxication, immobilizationHazardous Substances Data Bank (HSDB)
- EC50; Species: Daphnia pulex (Water Flea) age <24 hr; Conditions: freshwater, static, 20 °C, pH 7.6; Concentration: 174.27 mM for 24 hr; Effect: intoxication, immobilization /formulation/Hazardous Substances Data Bank (HSDB)
- LC50; Species: Artemia salina (Brine Shrimp) 2-3 instar larvae; Conditions: saltwater, static, salinity 35 ppt; Concentration: 278000 umol/L for 24 hr /formulation/Hazardous Substances Data Bank (HSDB)
13Disposal considerations
- SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.Hazardous Substances Data Bank (HSDB)
- SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal.Hazardous Substances Data Bank (HSDB)
- The following wastewater treatment technology has been investigated for isopropanol: Biological treatment.Hazardous Substances Data Bank (HSDB)
14Transport information
Shipping name
- UN 1219; Isopropanol or Isopropyl alcoholHazardous Substances Data Bank (HSDB)
- IMO 3.2; Isopropanol or Isopropyl alcoholHazardous Substances Data Bank (HSDB)
DOT hazard class
- First aid kitUS Code of Federal Regulations, Hazardous Materials, 49 CFR Part 172
- UN3316US Code of Federal Regulations, Hazardous Materials, 49 CFR Part 172
- Class 9 Miscellaneous hazardous material (49 eCFR § 173.140)US Code of Federal Regulations, Hazardous Materials, 49 CFR Part 172
DOT label
- Flammable LiquidCAMEO Chemicals
UN classification
- UN Hazard Class: 3; UN Pack Group: IIILO-WHO International Chemical Safety Cards (ICSCs)
Emergency Response Guidebook
- 1219 129Emergency Response Guidebook (ERG)
- 3316 171Emergency Response Guidebook (ERG)
15Regulatory information
- This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Isopropanol is produced, as an intermediate or a final product, by process units covered under this subpart.Hazardous Substances Data Bank (HSDB)
- Unless specifically excluded, residues resulting from the use of the following substances as either an inert or an active ingredient in a pesticide chemical formulation, including antimicrobial pesticide chemicals, are exempted from the requirement of a tolerance under FFDCA section 408, if such use is in accordance with good agricultural or manufacturing practices. 2-Propanol is included on this list.Hazardous Substances Data Bank (HSDB)
- Based on the reviews of the generic data for the active ingredients ethanol and isopropanol, the Agency has sufficient information on the health effects and on their potential for causing adverse effects in fish and wildlife and the environment. The Agency has determined that ethanol and isopropanol products, labeled and used as specified in this Reregistration Eligibility Decision, will not pose unreasonable risks or adverse effects to humans or the environment. Therefore, the Agency concludes that products containing ethanol and isopropanol for all uses are eligible for reregistration.Hazardous Substances Data Bank (HSDB)
- Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. 2-Propanol is included on this list. Effective date: 12/15/86; Sunset date: 12/15/96.Hazardous Substances Data Bank (HSDB)
- Isopropyl alcohol (without residue) may be used in inks for marking food supplements in tablet form, gum, and confectionery.Hazardous Substances Data Bank (HSDB)
Overview of SDS regulations (OSHA HazCom, WHMIS, REACH/CLP) →
16Other information
Compiled from PubChem CID 3776 and the sources it aggregates (attributed inline). Data retrieved 2026-10-12. This summary describes the pure substance and is not a supplier SDS.
Frequently asked questions about Isopropanol
What is the CAS number for Isopropanol?
The CAS Registry Number for Isopropanol is 67-63-0. Its EC (EINECS) number is 200-661-7. It is transported under UN 1219 / UN 3316.
Is Isopropanol hazardous?
Yes. Isopropanol is classified under GHS with the signal word “Danger”. Hazard statements: H225: Highly Flammable liquid and vapor; H319: Causes serious eye irritation; H336: May cause drowsiness or dizziness.
Is Isopropanol flammable?
Yes. Isopropanol is classified as a flammable hazard under GHS. Its reported flash point is 53 °F (NTP, 1992). Keep it away from heat, sparks, open flames and other ignition sources.
Which GHS pictograms apply to Isopropanol?
Isopropanol labels carry GHS02 (Flame) and GHS07 (Exclamation Mark).
What are the workplace exposure limits for Isopropanol?
OSHA PEL: 400 ppm (980 mg/m³). NIOSH REL: 400 ppm (980 mg/m³). ACGIH TLV: 8 hr Time Weighted Avg (TWA): 200 ppm; 15 min Short Term Exposure Limit (STEL): 400 ppm. IDLH: 2000 ppm ; Based on 10% of the lower explosive limit. (NIOSH, 2024).
What PPE is needed when handling Isopropanol?
Excerpt from NIOSH Pocket Guide for Isopropyl alcohol: Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact. Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact. Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated. Remove: WHEN WET (FLAMMABLE) - Work clothing that becomes wet should be immediately removed due to its flammability hazard (i.e., for liquids with a flash point <100 °F). Change: No recommendation is made specifying the need for the worker to change clothing after the workshift. (NIOSH, 2024)
What is the first aid for Isopropanol exposure?
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water.
How should Isopropanol be stored?
Fireproof. Separated from strong oxidants. Cool. Well closed.