O-Xylene

1Identification

Name

O-Xylene

IUPAC name

1,2-xylene

CAS number

95-47-6

EC number

202-422-2

Molecular formula

C8H10

Molecular weight

106.16 g/mol

InChIKey

CTQNGGLPUBDAKN-UHFFFAOYSA-N

SMILES

CC1=CC=CC=C1C

PubChem CID

7237

Synonyms

1,2-Dimethylbenzene, 1,2-Xylene, Ortho-Xylene, o-Xylol, o-Dimethylbenzene, o-Methyltoluene, 2-Xylene, 3,4-Xylene, Benzene, 1,2-dimethyl-, 1,2-Dimethylbenzol, 2-Methyltoluene, orthoxylene, RefChem:97, o-Xylenes

Recommended uses

• For 2-xylene (USEPA/OPP Pesticide Code: 086800) ACTIVE products with label matches. /SRP: Registered for use in the USA but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./
  Hazardous Substances Data Bank (HSDB)
• Manufacture of phthalic anhydride, vitamin and pharmaceutical syntheses, dyes, insecticides, motor fuels.
  Hazardous Substances Data Bank (HSDB)
• CHEM INTERMEDIATE FOR PHTHALONITRILE
  Hazardous Substances Data Bank (HSDB)
• Other Dispersing agent Solvent Fuel agents Antioxidant Monomers Not Known or Reasonably Ascertainable Intermediate
  EPA Chemical Data Reporting (CDR)
• Solvent Dispersing agent Intermediate Not Known or Reasonably Ascertainable
  EPA Chemical Data Reporting (CDR)

Description

• O-xylene appears as a colorless watery liquid with a sweet odor. Less dense than water. Insoluble in water. Irritating vapor. (USCG, 1999)
  CAMEO Chemicals
• O-xylene is a xylene substituted by methyl groups at positions 1 and 2.
  ChEBI
• O-xylene is an aromatic hydrocarbon based on benzene with two methyl substituents. It is a isomer of xylene. Xylene occurs naturally in petroleum and coal tar, and is major component of gasoline and fuel oil. Xylene is used mainly as a solvent and in the printing, rubber, and leather industries. O-xylene is largely used in the production of phthalic anhydride, and is generally extracted by distillation from a mixed xylene stream in a plant primarily designed for p-xylene production. Contrary to popular belief, a series of switch condensers is required, and not a complicated setup of distillation columns that never work (L938, T10, L165). It can cause irritation eyes, skin, nose, throat;
  Toxin and Toxin Target Database (T3DB)

2Hazard identification

Signal word

Warning

Pictograms

GHS02, GHS07

Classification source

Regulation (EC) No 1272/2008 of the European Parliament and of the Council

Precautionary statements

Other reported classifications

6 classification records exist across sources. Differences usually reflect purity, physical form or impurities.

NFPA 704 rating

• 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.
  Hazardous Substances Data Bank (HSDB)
• 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.
  Hazardous Substances Data Bank (HSDB)
• 0 - Materials that in themselves are normally stable, even under fire conditions.
  Hazardous Substances Data Bank (HSDB)

Health hazards

• Vapors cause headache and dizziness. Liquid irritates eyes and skin. If taken into lungs, causes severe coughing, distress, and rapidly developing pulmonary edema. If ingested, causes nausea, vomiting, cramps, headache, and coma. Can be fatal. Kidney and liver damage can occur. (USCG, 1999)
  CAMEO Chemicals

Fire hazards

• Behavior in Fire: Vapor is heavier than air and may travel considerable distance to a source of ignition and flash back. (USCG, 1999)
  CAMEO Chemicals
• Flammable. Above 30 °C explosive vapour/air mixtures may be formed.
  ILO-WHO International Chemical Safety Cards (ICSCs)

Hazards summary

• The major hazards encountered in the use and handling of 2-xylene stem from its toxicologic properties and flammability. Exposure to this colorless liquid may occur from its use as a chemical intermediate, as an industrial solvent, and as component of gasoline. Toxic by all routes of exposure (ie, dermal, ingestion, and inhalation), 2-xylene can cause effects including headache, dizziness, skin and eye irritation, kidney and liver damage, pulmonary edema, coma, and death. The ACGIH recommends a workplace exposure limit (TLV) of 100 ppm as an 8 hr time-weighted average (TWA);
  Hazardous Substances Data Bank (HSDB)

3Composition / information on ingredients

This page describes the pure substance. Commercial products may be solutions or mixtures. Check Section 3 of your supplier's SDS for concentrations and other ingredients.

4First-aid measures

• EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water.
  CAMEO Chemicals
• (General first aid procedures) Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Skin: Soap wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly. Breathing: Respiratory support Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.
  The National Institute for Occupational Safety and Health (NIOSH)

Symptoms of exposure

• Dizziness. Drowsiness. Headache. Nausea.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• Dry skin. Redness.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• Redness. Pain.
  ILO-WHO International Chemical Safety Cards (ICSCs)

5Fire-fighting measures

• Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
  Hazardous Substances Data Bank (HSDB)
• Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.
  Hazardous Substances Data Bank (HSDB)
• Use water spray to cool unopened containers.
  Hazardous Substances Data Bank (HSDB)

6Accidental release measures

Isolation and evacuation

• Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
  CAMEO Chemicals

Spill cleanup

• Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
  Hazardous Substances Data Bank (HSDB)
• Stop discharge if possible. Keep people away. Call fire department. Avoid contact with liquid and vapor. Isolate and remove discharged material. Notify local health and pollution control agencies.
  Hazardous Substances Data Bank (HSDB)

7Handling and storage

• Fireproof. Store only in original container. Separated from strong oxidants and strong acids. Store in an area without drain or sewer access.
  ILO-WHO International Chemical Safety Cards (ICSCs)
• Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Flammable liquids.
  Hazardous Substances Data Bank (HSDB)

8Exposure controls / personal protection

Personal protective equipment

• Excerpt from NIOSH Pocket Guide for o-Xylene: Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact. Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact. Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated. Remove: WHEN WET (FLAMMABLE) - Work clothing that becomes wet should be immediately removed due to its flammability hazard (i.e., for liquids with a flash point <100 °F). Change: No recommendation is made specifying the need for the worker to change clothing after the workshift. (NIOSH, 2024)
  CAMEO Chemicals
• Eye/face protection: Face shield and safety glasses. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
  Hazardous Substances Data Bank (HSDB)
• Skin protection: Handle with gloves.
  Hazardous Substances Data Bank (HSDB)
• Body Protection: Complete suit protecting against chemicals. Flame retardant antistatic protective clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
  Hazardous Substances Data Bank (HSDB)

Respirator recommendations

• NIOSH/OSHA Up to 900 ppm: (APF = 10) Any chemical cartridge respirator with organic vapor cartridge(s)* (APF = 25) Any powered, air-purifying respirator with organic vapor cartridge(s)* (APF = 10) Any supplied-air respirator* (APF = 50) Any self-contained breathing apparatus with a full facepiece Emergency or planned entry into unknown concentrations or IDLH conditions: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode (APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-co…
  The National Institute for Occupational Safety and Health (NIOSH)

9Physical and chemical properties

10Stability and reactivity

Reactivity

• O-XYLENE may react with oxidizing materials. (NTP, 1992).
  CAMEO Chemicals
• Highly flammable. Insoluble in water.
  CAMEO Chemicals

Incompatible materials and hazardous reactions

• Incompatible materials: Oxidizing agents.
  Hazardous Substances Data Bank (HSDB)
• Strong oxidizers, strong acids.
  Hazardous Substances Data Bank (HSDB)
• Strong oxidizers, strong acids
  The National Institute for Occupational Safety and Health (NIOSH)

Chemical stability

• Stable under recommended storage conditions.
  Hazardous Substances Data Bank (HSDB)

11Toxicological information

Target organs

• Eyes, skin, respiratory system, central nervous system, gastrointestinal tract, blood, liver, kidneys
  The National Institute for Occupational Safety and Health (NIOSH)

Short-term exposure effects

• The substance is irritating to the eyes and skin. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. The substance may cause effects on the central nervous system. This may result in impaired functions.
  ILO-WHO International Chemical Safety Cards (ICSCs)

Long-term exposure effects

• The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the central nervous system. Animal tests show that this substance possibly causes toxicity to human reproduction or development.
  ILO-WHO International Chemical Safety Cards (ICSCs)

12Ecological information

Not available in the public sources we compile. Check Section 12 of the supplier's SDS.

13Disposal considerations

• Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U239 and F003, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.
  Hazardous Substances Data Bank (HSDB)
• SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal.
  Hazardous Substances Data Bank (HSDB)
• Product: Contact a licensed professional waste disposal service to dispose of this material. Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company; Contaminated packaging: Dispose of as unused product.
  Hazardous Substances Data Bank (HSDB)

14Transport information

UN number: UN 1307

Shipping name

• UN 1307; Xylenes.
  Hazardous Substances Data Bank (HSDB)
• IMO 3; Xylenes
  Hazardous Substances Data Bank (HSDB)

DOT label

• Flammable Liquid
  CAMEO Chemicals

UN classification

• UN Hazard Class: 3; UN Pack Group: III
  ILO-WHO International Chemical Safety Cards (ICSCs)

Emergency Response Guidebook

• 1307 130
  The National Institute for Occupational Safety and Health (NIOSH)

How DOT hazard classes work →

15Regulatory information

• This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. o-Xylene is produced, as an intermediate or a final product, by process units covered under this subpart.
  Hazardous Substances Data Bank (HSDB)
• o-Xylene is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.
  Hazardous Substances Data Bank (HSDB)
• Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).
  Hazardous Substances Data Bank (HSDB)
• Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. o-Xylene is included on this list. Effective date 10/4/82; Sunset date: 10/4/92.
  Hazardous Substances Data Bank (HSDB)
• F003; When xylene is a spent solvent, it is classified as a hazardous waste from a nonspecific source (F003), as stated in 40 CFR 261.31, and must be managed according to State and/or Federal hazardous waste regulations. /Xylenes/
  Hazardous Substances Data Bank (HSDB)

Overview of SDS regulations (OSHA HazCom, WHMIS, REACH/CLP) →

16Other information

Compiled from PubChem CID 7237 and the sources it aggregates (attributed inline). Data retrieved 2026-10-12. This summary describes the pure substance and is not a supplier SDS.